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Published on: May 10, 2024
Targeted therapy in gastric cancer
Alexandra Thiel1, Ari Ristimäki
1Department of Pathology, HUSLAB and Haartman Institute, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Genome-Scale Biology, Research Programs Unit, University of Helsinki, Helsinki, Finland.
Targeted therapies like trastuzumab and ramucirumab show promise for advanced gastric cancer. While some targeted agents lack survival benefits, ongoing research into c-MET/HGF inhibitors offers new hope for patients.
Area of Science:
- Oncology
- Molecular Biology
- Gastroenterology
Background:
- Gastric cancer is frequently diagnosed at advanced stages, leading to poor prognoses despite chemotherapy.
- Recent advancements in understanding gastric carcinogenesis have paved the way for novel targeted therapies.
Purpose of the Study:
- To review the current landscape of targeted treatment options for gastric cancer.
- To summarize the efficacy and ongoing investigations of various targeted agents in gastric cancer management.
Main Methods:
- Literature review of clinical trials and research on targeted therapies for gastric cancer.
- Analysis of data on agents targeting HER-2, VEGFR-2, EGFR, VEGF-A, mTOR, and c-MET/HGF.
Main Results:
- Trastuzumab (anti-HER2) improves survival in HER2-overexpressing advanced gastric cancer.
- Ramucirumab (anti-VEGFR-2) demonstrates promising clinical trial results.
- Agents targeting EGFR, VEGF-A, and mTOR have not shown clear survival benefits.
Conclusions:
- Targeted therapies represent a significant advancement in gastric cancer treatment, particularly for specific molecular subtypes.
- Ongoing research, including c-MET/HGF inhibitors, continues to expand therapeutic options for advanced gastric cancer.
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