Related Experiment Video
Updated: Apr 17, 2026

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
Published on: October 24, 2025
ACR appropriateness Criteria® infertility
Darci J Wall1, Marcia C Javitt, Phyllis Glanc
1*Mayo Clinic, Rochester, Minnesota; †Rambam Healthcare Campus, Haifa, Israel; ‡Sunnybrook Health Sciences Centre, Bayview Campus, Toronto, Ontario, Canada; §University of Texas MD Anderson Cancer Center, Houston, Texas; ∥Massachusetts General Hospital, Boston Massachusetts; ¶Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; #George Washington University Hospital, Washington, District of Columbia; **Thomas Jefferson University Hospital, Philadelphia, Pennsylvania; ††The Old Vicarage. Worcester Park, United Kingdom; ‡‡Massachusetts General Hospital, Boston Massachusetts; §§Memorial Sloan Kettering Cancer Center, New York, New York; ∥∥Brigham & Women's Hospital, Boston, Massachusetts, American College of Obstetrics and Gynecology; ¶¶Mallinckrodt Institute of Radiology, St. Louis, Missouri; ##Columbia University, New York, New York, American College of Obstetrics and Gynecology; ***University of Maryland School of Medicine, Baltimore, Maryland; and †††Valley Hospital, Ridgewood, New Jersey, American College of Obstetrics and Gynecology.
Choosing the right imaging for infertility depends on suspected causes. Transvaginal ultrasound is key for PCOS, while MRI and pelvic ultrasound aid endometriosis evaluation. HSG is preferred for tubal occlusion concerns.
Area of Science:
- Radiology
- Women's Health
- Reproductive Medicine
Background:
- Infertility affects a significant portion of women, with various underlying causes.
- Accurate diagnosis of infertility causes is crucial for effective treatment.
- Imaging plays a pivotal role in the infertility workup.
Purpose of the Study:
- To outline appropriate imaging modalities for evaluating female infertility based on clinical suspicion.
- To provide guidance on selecting the optimal imaging technique for specific infertility-related conditions.
- To highlight the role of imaging in diagnosing causes of anovulatory infertility, endometriosis, tubal occlusion, recurrent pregnancy loss, and pituitary abnormalities.
Main Methods:
- Review of the American College of Radiology Appropriateness Criteria.
- Evidence-based guidelines developed through multidisciplinary expert panel review.
- Analysis of current medical literature and consensus methodology (modified Delphi).
Main Results:
- Transvaginal ultrasound is recommended for assessing polycystic ovary syndrome (PCOS).
- MRI and pelvic ultrasound are valuable for suspected endometriosis.
- Hysterosalpingogram (HSG) is the preferred method for evaluating suspected tubal occlusion.
- Saline infusion sonohysterography, MRI, and 3-D ultrasound are appropriate for anatomical causes of recurrent pregnancy loss (RPL).
- MRI is the imaging exam of choice for pituitary gland assessment.
Conclusions:
- The selection of imaging for infertility workup should be guided by clinical suspicion and the suspected underlying cause.
- Specific imaging modalities are most appropriate for diagnosing distinct causes of infertility, including PCOS, endometriosis, tubal factors, uterine anomalies, and pituitary issues.
- Adherence to evidence-based guidelines ensures appropriate and effective utilization of imaging in female infertility evaluation.
Related Concept Videos
Infertility in Females
Endometriosis, a condition characterized by abnormal growth of...
Infertility in Males
In Vitro Fertilization
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

