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Plasma calcium difference between man and vertebrates.

F C Driessens1, R M Verbeeck, J W van Dijk

  • 1Department of Oral Biomaterials, Catholic University, Nijmegen, The Netherlands.

Comparative Biochemistry and Physiology. A, Comparative Physiology
|January 1, 1989
PubMed
Summary
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Healthy animal and human blood plasma shows varying saturation levels with octocalcium phosphate (OCP). Young individuals exhibit higher saturation than adults, with adult humans being slightly undersaturated.

Area of Science:

  • Biochemistry
  • Comparative Physiology
  • Human Physiology

Background:

  • Plasma calcium and phosphate homeostasis is critical for health.
  • Ionized calcium constitutes approximately 45% of total plasma calcium.
  • Octocalcium phosphate (OCP) is a key mineral phase in biological systems.

Purpose of the Study:

  • To analyze plasma saturation with octocalcium phosphate (OCP) in healthy individuals.
  • To compare OCP saturation levels across different age groups and species.
  • To investigate age- and species-related differences in calcium-phosphate balance.

Main Methods:

  • Literature review of plasma total calcium, ionized calcium, and inorganic phosphate data.
  • Calculation of the degree of saturation with respect to OCP.

Related Experiment Videos

  • Comparative analysis of saturation levels based on age and species.

    • Main Results:

    • Plasma ionized calcium is consistently around 45% of total calcium in healthy subjects.
    • Young animals and humans show higher plasma saturation with OCP compared to adults.
    • Healthy animals remain supersaturated with OCP throughout life, while adult humans are slightly undersaturated.

    Conclusions:

    • Age significantly influences plasma OCP saturation in both animals and humans.
    • Adult human plasma exhibits a unique undersaturation with OCP compared to healthy animals.
    • These findings highlight species- and age-specific variations in calcium-phosphate regulation.