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The mouse Cebp gene encoding a DNA-binding protein is polymorphic and is located on chromosome 7
K G Xanthopoulos1, J Mirkovitch, J M Friedman
1Rockefeller University, New York, NY 10021.
Cytogenetics and Cell Genetics
|January 1, 1989
Summary
The mouse Cebp gene, which codes for the C/EBP DNA-binding protein, was located on chromosome 7. This was achieved by analyzing a specific genetic marker across different mouse strains.
Area of Science:
- Genetics
- Molecular Biology
- Genomics
Background:
- The CCAAT/enhancer-binding protein (C/EBP) family are transcription factors crucial for cellular differentiation and metabolism.
- Gene mapping is essential for understanding genetic regulation and disease association.
Purpose of the Study:
- To map the location of the mouse Cebp gene.
- To identify the chromosomal location of the Cebp gene within the mouse genome.
Main Methods:
- Utilized restriction fragment length polymorphism (RFLP) analysis.
- Examined strain distribution patterns (SDP) in BXD and AKXL recombinant inbred (RI) mouse lines.
Main Results:
- The mouse Cebp gene was successfully localized to the proximal region of chromosome 7.
- The RFLP analysis provided a clear strain distribution pattern for Cebp.
Conclusions:
- The chromosomal assignment of the Cebp gene provides a foundation for further genetic studies.
- This localization aids in understanding the genetic architecture controlling C/EBP function in mice.