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Related Experiment Videos

Selected mouse lines, alcohol and behavior.

T J Phillips1, D J Feller, J C Crabbe

  • 1VA Medical Center, Research Service, Portland, Oregon 97201.

Experientia
|September 15, 1989
PubMed
Summary
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Selective breeding created genetically distinct mouse models to study alcohol's effects. These models reveal that different genes influence various alcohol responses, challenging single-gene theories and highlighting GABA and dopamine roles.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Genetics

Background:

  • Selective breeding has produced mouse lines with varying genetic sensitivity to ethanol's effects.
  • These genetic animal models are crucial for understanding alcohol's impact on hypnosis, thermoregulation, excitation, and dependence.

Purpose of the Study:

  • To investigate the genetic underpinnings of ethanol's diverse effects.
  • To identify specific neurochemical and neurophysiological mechanisms of alcohol action.
  • To challenge existing beliefs regarding ethanol's mechanisms of action.

Main Methods:

  • Development of genetically distinct mouse lines through selective breeding for differential ethanol sensitivity.
  • Utilizing these mouse models in numerous studies to analyze genetic differences and neurobiological bases of ethanol's actions.

Related Experiment Videos

  • Comparative analysis of sensitivity to ethanol and other drugs across different mouse lines.

    • Main Results:

    • No single set of genes modulates all ethanol effects; sensitivity varies across different alcohol-induced responses.
    • Mice selected for ethanol anesthesia sensitivity (LS mice) do not show uniform sensitivity to all anesthetic drugs, indicating diverse mechanisms.
    • Mice susceptible to ethanol withdrawal (WSP mice) also exhibit predisposition to diazepam and phenobarbital withdrawal, suggesting shared genetic factors in drug dependence.

    Conclusions:

    • Ethanol's diverse effects are mediated by distinct genetic factors, refuting a unified genetic control.
    • Genetic animal models provide powerful tools to dissect complex drug actions and dependencies.
    • Future research should focus on gamma-aminobutyric acid and dopamine systems for understanding alcohol intoxication susceptibility.