Related Experiment Video
Updated: Apr 17, 2026
Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation
Published on: October 25, 2024
Does ovarian reserve predict egg quality in unstimulated therapeutic donor insemination cycles?
Mike Ripley1, Andrea Lanes2, Marie-Claude Léveillé1
1Ottawa Fertility Centre, University of Ottawa, Ottawa, Ontario, Canada.
Objective:
To compare reproductive outcomes of patients with very low, low, normal, and high antral follicle counts undergoing unstimulated therapeutic donor insemination (TDI) cycles.
Design:
Retrospective cohort study.
Setting:
University-affiliated regional fertility clinic.
Patient(S):
Four hundred fifty-nine patients who had 1,107 TDI treatment cycles from January 2006 to December 2013.
Intervention(S):
Unstimulated therapeutic donor insemination.
Main Outcome Measure(S):
Clinical pregnancy rates and miscarriage rates as surrogate markers for oocyte quality.
Result(S):
The overall pregnancy rate per cycle start was 12.46% in the study population. There was no difference in per-cycle or cumulative pregnancy rates among patients with very low, low, average, or high antral follicle counts within each patient age group of ≤35, 36-39, and ≥40 years. The overall miscarriage rate per pregnancy was 13.61%. When stratified by patient age, there was no correlation between miscarriage rate and antral follicle count.
Conclusion(S):
AFC is not a predictor of pregnancy or miscarriage rates in patients undergoing unstimulated TDI.
