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IRAK4 gene polymorphism and odontogenic maxillary sinusitis.

Inês Guerra Pereira1, Paula Vaz2, Ricardo Faria Almeida3

  • 1Department of Oral Surgery, Faculty of Dentistry, Oporto University, Rua Dr. Manuel Pereira da Silva, 4200 393, Porto, Portugal. inesguerrapereira@gmail.com.

Clinical Oral Investigations
|February 25, 2015
PubMed
Summary

A specific interleukin-1 receptor-associated kinase-4 (IRAK4) gene polymorphism may influence maxillary sinus changes, especially with dental issues. A predictive model incorporating genetic and clinical factors achieved 91.1% accuracy in identifying inflammatory responses.

Keywords:
Genetic polymorphismGenetic predispositionIRAK-4 human proteinMaxillary sinusitis

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Area of Science:

  • Genetics and Oral Medicine
  • Biomarkers in Sinusitis
  • Computational Biology in Healthcare

Background:

  • Maxillary sinus inflammatory changes are often linked to dental issues.
  • The role of specific genetic polymorphisms, like IRAK4, in this process requires further investigation.
  • Accurate prediction of sinus involvement aids in effective dental treatment planning.

Purpose of the Study:

  • To assess the influence of an Interleukin-1 receptor-associated kinase-4 (IRAK4) gene polymorphism on maxillary sinus changes.
  • To identify etiological factors, particularly of dental origin, contributing to maxillary sinus inflammation.
  • To develop a predictive model for maxillary sinus inflammatory responses.

Main Methods:

  • Retrospective analysis of 504 CT scans from 153 Portuguese Caucasians.
  • Genetic testing for IRAK4 gene polymorphism.
  • Logistic analysis, regression coefficients, Chi test, Fisher's exact test, and ROC curve analysis were employed.

Main Results:

  • The prevalence of IRAK4 gene polymorphism in the study population was 26.8%.
  • A predictive model was constructed using variables: prior sinusitis, sinus pressure, CT-observed cortical bone loss, positive IRAK4 genetic test, and tooth root proximity to the sinus.
  • The model demonstrated high predictive accuracy (AUC = 0.91, 91.1% correct prediction).

Conclusions:

  • The developed model serves as a valuable initial clinical tool for predicting maxillary sinus inflammatory responses.
  • The study highlights the potential role of IRAK4 gene polymorphism as a risk factor.
  • The model can assist clinicians in managing complex dental cases involving the maxillary sinus.