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Updated: Apr 17, 2026
In Vivo Mouse Model of Spinal Implant Infection
Published on: June 23, 2020
Risk factors for surgical site infection following pediatric spinal deformity surgery: a systematic review and
Fei Meng1, Junming Cao, Xianzhong Meng
1Department of Orthopedics, The Third Hospital of Hebei Medical University, 139 Ziqiang Road, Shijiazhuang, Hebei, 050051, People's Republic of China.
Purpose:
This study was conducted to identify risk factors for postoperative infection after pediatric spinal deformity surgery.
Methods:
A systematic electronic literature search from inception to November 2014 was performed in the following databases: Pubmed, Embase, and Cochrane library databases. Pooled odds ratios (ORs) or standardized mean differences (SMDs) with 95 % confidence intervals (CIs) were calculated using random or fixed effects model. Newcastle-Ottawa scale was used to evaluate the methodological quality, and Stata 11.0 was used to analyze data.
Results:
The main factors associated with infection after spinal surgery were idiopathic scoliosis (OR, 0.303; 95 % CI, 0.202-0.453), neuromuscular scoliosis (OR, 2.269; 95 % CI, 1.576-3.267), ambulatory status (OR, 0.241; 95 % CI, 0.078-0.747), previous spinal surgery (OR, 4.564; 95 % CI, 1.892-11.009), sacral vertebrae fused (OR, 2.717; 95 % CI, 1.836-4.020), and allograft (OR, 8.498; 95 % CI, 4.030-17.917). There was no sufficient evidence to reveal that male gender, age, body mass index, preoperative curve, preoperative urinary tract infection, combined anterior-posterior approach, estimated blood loss, and operating room time could lead to infection after spinal surgery.
Conclusions:
We identified some risk factors which could be used to prevent the onset of surgical site infection in pediatric spinal deformity surgery. However, the results of this meta-analysis should be interpreted with caution because of the heterogeneity among the studies.
