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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
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Databases and web tools for cancer genomics study.

Yadong Yang1, Xunong Dong2, Bingbing Xie2

  • 1CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.

Genomics, Proteomics & Bioinformatics
|February 25, 2015
PubMed
Summary
This summary is machine-generated.

This study reviews web resources for cancer genomics research, evaluating data diversity, sample size, omics comprehensiveness, and user experience to aid researchers. The goal is to increase awareness and use of these valuable cancer genomics tools.

Keywords:
CancerCollaborationData integrationGenomicsResource

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Area of Science:

  • Bioinformatics
  • Genomics
  • Cancer Research

Background:

  • Publicly accessible resources are crucial for advancing scientific discovery.
  • The genomics and big data era necessitates collaboration and data sharing for knowledge utilization.

Purpose of the Study:

  • To describe and evaluate web resources for cancer genomics research.
  • To assess resources based on cancer type diversity, sample size, omics data comprehensiveness, and user experience.

Main Methods:

  • Review of publicly available web resources for cancer genomics.
  • Rating of resources on key criteria including data diversity, sample size, omics data comprehensiveness, and user experience.

Main Results:

  • Identification and evaluation of various data repository and analysis tools for cancer genomics.
  • Assessment of the strengths and weaknesses of different cancer genomics resources.

Conclusions:

  • Awareness and utilization of cancer genomics resources can be enhanced through such reviews.
  • Facilitating the use of these resources will support the cancer research community.