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Related Experiment Videos

Minor tranquillizers in somatic disorders.

C Krogh, W M McLean, Y D LaPierre

    Canadian Medical Association Journal
    |May 6, 1978
    PubMed
    Summary
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    What are the issues surrounding long-term benzodiazepine treatment for generalized anxiety disorder.

    Journal of psychiatry & neuroscience : JPN·2001

    Adjunctive anxiolytic therapy offers limited benefits for somatic conditions, potentially aiding patient management and well-being in specific cases like gastrointestinal disorders. Caution is advised due to potential negative effects, particularly with benzodiazepines in respiratory and hypertensive conditions.

    Area of Science:

    • Medical Science
    • Pharmacology

    Background:

    • Adjunctive anxiolytic therapy is sometimes used in managing somatic conditions.
    • Evidence for improved outcomes with anxiolytics in somatic conditions is often inconclusive.
    • Anxiolytics may influence patient well-being and management rather than offering a cure.

    Purpose of the Study:

    • To evaluate the efficacy and safety of adjunctive anxiolytic therapy in various somatic conditions.
    • To determine the specific benefits and risks associated with anxiolytic use in different patient populations.
    • To provide guidance on the judicious use of anxiolytics in clinical practice.

    Main Methods:

    • Review of existing literature on anxiolytic therapy in somatic disorders.
    • Analysis of clinical outcomes and adverse effects reported in relevant studies.

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  • Case-by-case evaluation of potential benefits versus risks.

    • Main Results:

    • Lack of conclusive evidence for improved outcomes in many somatic conditions.
    • Potential benefits in patient management and well-being for gastrointestinal disorders, migraine, and myocardial infarction.
    • Adverse effects, particularly with benzodiazepines, noted in acute respiratory conditions and hypertension.

    Conclusions:

    • Adjunctive anxiolytic therapy may not be curative but can facilitate patient management and improve well-being in select somatic conditions.
    • Benzodiazepines should be used cautiously in respiratory conditions due to potential negative effects.
    • Anxiolytics appear to offer no benefit and may be detrimental in hypertension; careful individual assessment and planned termination are crucial.