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Correlation of Childhood Obesity and Related Insulin Resistance with Leptin and Retinol Binding Protein 4

Vasanthi Thiruvengadam1, Sumanth Amperayani, R Prakash Babu

  • 1Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital and The CHILDS Trust Medical Research Foundation, Chennai, Tamil Nadu, 600034, India, dr_vasanthi@hotmail.com.

Indian Journal of Pediatrics
|February 25, 2015
PubMed

Insights

This study investigated obesity in children, finding abnormal leptin levels in all participants and high retinol binding protein 4 (RBP4) in most. However, no significant link was found between insulin resistance and RBP4 levels.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Metabolic Research

Background:

  • Obesity is a growing global health concern in children.
  • Metabolic dysfunction, including insulin resistance, is a common comorbidity of childhood obesity.
  • Retinol Binding Protein 4 (RBP4) is a protein secreted by adipocytes and the liver, implicated in insulin resistance.

Purpose of the Study:

  • To examine the relationship between obesity and various metabolic parameters in children.
  • To investigate the correlation between insulin resistance and levels of leptin and retinol binding protein 4 (RBP4).

Main Methods:

  • A cross-sectional study was conducted at a tertiary care children's hospital.
  • 98 obese children were enrolled.
  • Metabolic parameters, insulin resistance, and RBP4 levels were analyzed.

Main Results:

  • All participating children exhibited abnormal leptin levels.
  • Elevated RBP4 levels were detected in 69.6% of the children.
  • No statistically significant association was observed between insulin resistance and RBP4 levels (p = 0.8).

Conclusions:

  • While RBP4 has been suggested to play a role in insulin resistance, this study did not find a significant positive association in obese children.
  • Further research may be needed to clarify the role of RBP4 in pediatric metabolic disorders.
Abstract

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