Related Experiment Video
Updated: Apr 17, 2026
05:19
A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
Published on: November 7, 2025
1.1K
Radiotherapy for high-risk prostate cancer
Jahan J Mohiuddin1, Brock R Baker1, Ronald C Chen1
1Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Nature Reviews. Urology
|February 25, 2015
Summary
Combining radiation therapy and long-term androgen deprivation therapy (ADT) improves survival for men with high-risk prostate cancer. Advanced radiation techniques and ongoing research promise even better outcomes.
Area of Science:
- Oncology
- Radiation Oncology
- Urology
Background:
- High-risk prostate cancer necessitates aggressive treatment strategies.
- Combined modality treatments, including radiation and androgen deprivation therapy (ADT), have demonstrated survival benefits.
Purpose of the Study:
- To review the established efficacy of combined radiation and long-term ADT for high-risk prostate cancer.
- To discuss advancements in radiation technology and ongoing research for improved patient outcomes.
Main Methods:
- Review of multiple clinical trials and practice guidelines.
- Analysis of data supporting current treatment recommendations.
- Exploration of emerging research in radiation techniques and novel hormonal agents.
Main Results:
- Combined radiation and long-term ADT significantly prolongs overall survival compared to monotherapy.
- Higher radiation doses, enabled by new technologies, improve cancer control.
- Current guidelines recommend at least 75.6 Gy radiation with 2-3 years of ADT for high-risk disease.
Conclusions:
- The combination of radiation and long-term ADT is a standard of care for high-risk prostate cancer.
- Technological advancements in radiation therapy are enhancing treatment efficacy.
- Future research directions, including hypofractionation and novel agents, hold potential for further survival improvements.
More Related Videos
Related Concept Videos
02:56Treatment Resistent Cancers
1.5K
1.5K
02:56Treatment Resistant Cancers
3.9K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K
02:57Targeted Cancer Therapies
9.2K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.2K
02:49Cancer Therapies
10.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.8K