Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

KDIGO 2025 ADPKD guideline through pediatric eyes.

Pediatric nephrology (Berlin, Germany)·2025
Same author

A randomized controlled trial evaluated the effect of pravastatin on kidney disease outcomes in adult patients with early-stage autosomal dominant polycystic kidney disease.

Kidney international·2025
Same author

Monitoring of Allograft Adaptation After Kidney Transplantation in Pediatric Patients by Targeted Plasma Metabolomics.

International journal of molecular sciences·2025
Same author

Clesrovimab for Prevention of RSV Disease in Healthy Infants.

The New England journal of medicine·2025
Same author

Dynamics of Respiratory Syncytial Virus Illness and Serology During Pregnancy and Infancy in the United States and South Africa.

Open forum infectious diseases·2025
Same author

Human Metapneumovirus-, Respiratory Syncytial Virus-, and Influenza-Associated Pneumonia Hospitalizations in Colorado Adults Aged ≥50 Years, 2016-2023.

The Journal of infectious diseases·2025

Related Experiment Video

Updated: Apr 17, 2026

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

16.4K

Intravenous acyclovir and renal dysfunction in children: a matched case control study.

Suchitra Rao1, Mark J Abzug1, Phyllis Carosone-Link1

  • 1Department of Pediatrics (Infectious Diseases and Hospital Medicine), University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO.

The Journal of Pediatrics
|February 25, 2015
PubMed
Summary

Intravenous acyclovir can cause acute kidney injury in children, with higher doses and certain co-medications increasing risk. Monitoring renal function is crucial, and doses should be kept below established thresholds to minimize nephrotoxicity.

More Related Videos

Intravenous Microinjections of Zebrafish Larvae to Study Acute Kidney Injury
15:55

Intravenous Microinjections of Zebrafish Larvae to Study Acute Kidney Injury

Published on: August 4, 2010

23.5K
Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

17.9K

Related Experiment Videos

Last Updated: Apr 17, 2026

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

16.4K
Intravenous Microinjections of Zebrafish Larvae to Study Acute Kidney Injury
15:55

Intravenous Microinjections of Zebrafish Larvae to Study Acute Kidney Injury

Published on: August 4, 2010

23.5K
Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

17.9K

Area of Science:

  • Pediatric Nephrology
  • Infectious Diseases
  • Clinical Pharmacology

Background:

  • A cluster of acute renal failure cases in children treated with intravenous acyclovir prompted this investigation.
  • Intravenous acyclovir is a critical antiviral medication for treating serious infections like meningoencephalitis in children.

Purpose of the Study:

  • To determine the incidence and risk factors of acute kidney injury (AKI) associated with intravenous acyclovir in pediatric patients.
  • To identify specific patient and treatment parameters that increase the risk of nephrotoxicity.

Main Methods:

  • A retrospective case-control study design was employed.
  • Renal function was assessed using modified Pediatric Risk Injury, Failure, Loss, End-Stage Renal Disease criteria based on creatinine measurements.
  • Univariate and multivariate analyses identified risk factors for nephrotoxicity.

Main Results:

  • Nephrotoxicity occurred in 35% of treatment courses, with 22% classified as risk, 9.7% as injury, and 3.8% as failure.
  • Higher acyclovir doses (>15 mg/kg), cumulative exposure exceeding 500 mg/m²/dose, older age (>8 years), and coadministration with ceftriaxone were significant risk factors.
  • Most renal dysfunction developed within 48 hours of initiating acyclovir treatment.

Conclusions:

  • Acute kidney injury from intravenous acyclovir is common in children and requires vigilant renal function monitoring.
  • Key risk factors include higher drug dosage, older age, and concurrent use of ceftriaxone.
  • Optimizing acyclovir dosing below 500 mg/m²/dose or 15 mg/kg/dose, especially in older children, may reduce the incidence of nephrotoxicity.