Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

5.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
5.0K
Stem Cell Culture01:17

Stem Cell Culture

6.7K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.7K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K
Embryonic Stem Cells00:58

Embryonic Stem Cells

33.5K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
33.5K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

6.1K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
6.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary omega-6 lipids promote post-injury aberrant bone formation in obesity.

The Journal of clinical investigation·2026
Same author

Sensory nerves protect against preclinical tendinopathic changes through FGF1 signaling.

Science translational medicine·2026
Same author

Sex-dependent mechanisms of temporomandibular joint osteoarthritis.

JBMR plus·2026
Same author

Boosting Sensory Nerve-to-Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Aging brain, brittle bone.

Trends in neurosciences·2026
Same author

A mouse growth plate injury model identified contributions of Pdgfra and Pdgfrb cellular descendants to bony bar formation.

Stem cells (Dayton, Ohio)·2026

Related Experiment Video

Updated: Apr 17, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

22.4K

Stem cell technology for bone regeneration: current status and potential applications.

Greg Asatrian1, Dalton Pham2, Winters R Hardy3

  • 1Dental and Craniofacial Research Institute and Section of Orthodontics, School of Dentistry, Los Angeles, CA, USA.

Stem Cells and Cloning : Advances and Applications
|February 25, 2015
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells (MSC) offer revolutionary potential for bone tissue engineering and regeneration. This review explores MSC origins, applications, and safety for skeletal repair, highlighting future clinical possibilities.

Keywords:
ASCDMSCMSCbone tissue engineeringmesenchymal stem cellpericyte

More Related Videos

Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications
10:30

Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications

Published on: December 8, 2016

10.5K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.7K

Related Experiment Videos

Last Updated: Apr 17, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

22.4K
Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications
10:30

Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications

Published on: December 8, 2016

10.5K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.7K

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Mesenchymal stem cells (MSC) have significantly advanced tissue engineering, especially in skeletal regenerative medicine.
  • Despite progress, knowledge gaps exist regarding MSC origins, optimal populations for bone regeneration, and biologic safety of unpurified cells.

Purpose of the Study:

  • To review the discovery, applications, and future potential of MSC in bone tissue engineering.
  • To debate the advantages and disadvantages of MSC from various tissue origins (adipose, bone marrow, dental pulp).
  • To discuss the perivascular origin of MSC and briefly touch upon pluripotent stem cells for bone regeneration.

Main Methods:

  • Literature review summarizing current knowledge and future directions.
  • Comparative analysis of MSC populations from different tissue sources.
  • Discussion of MSC origin and potential alternative stem cell applications.

Main Results:

  • Mesenchymal stem cells (MSC) show great promise for bone regeneration.
  • Different MSC sources (adipose, bone marrow, dental pulp) present unique advantages and disadvantages.
  • The perivascular origin of MSC is a key area of ongoing research.

Conclusions:

  • Mesenchymal stem cell (MSC)-based bone tissue engineering is rapidly advancing.
  • Further research into MSC origins, safety, and specific population advantages is crucial for clinical translation.
  • MSC-based therapies hold significant potential for becoming a clinical reality in skeletal regenerative medicine.