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Sono-elastography for Differentiating Benign and Malignant Cervical Lymph Nodes: A Systematic Review and
Mahsa Ghajarzadeh1, Mehdi Mohammadifar2, Kamran Azarkhish2
1Department of Neurology, Brain and Spinal Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran.
International Journal of Preventive Medicine
|February 25, 2015
Summary
Sono-elastography accurately differentiates benign from malignant cervical lymph nodes (LNs). This review found high sensitivity and specificity, making it a valuable diagnostic tool for cervical LNs.
Area of Science:
- Medical Imaging
- Diagnostic Accuracy
- Oncology
Background:
- Cervical lymph node (LN) evaluation is crucial for cancer staging.
- Sono-elastography offers a non-invasive method to assess tissue stiffness.
Purpose of the Study:
- To systematically review and meta-analyze the diagnostic accuracy of sono-elastography for cervical lymph nodes (LNs).
Main Methods:
- Systematic literature search of multiple databases up to December 2012.
- Meta-analysis of 10 eligible studies evaluating 936 cervical LNs (502 malignant, 434 benign).
- Analysis of sono-elastography scoring and strain ratio (SR) measurements.
Main Results:
- Summary sensitivity for differentiation: 0.76 (scoring) and 0.83 (SR).
- Summary specificity for differentiation: 0.80 (scoring) and 0.84 (SR).
- Area under the curve (AUC) was 0.86 (scoring) and 0.95 (SR).
Conclusions:
- Sono-elastography demonstrates high accuracy in distinguishing benign from malignant cervical LNs.
- Strain ratio measurements show particularly high diagnostic performance.
