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Pomegranate Flower Extract does not Prevent Cisplatin-Induced Nephrotoxicity in Female Rats
Sima Jilanchi1, Mehdi Nematbakhsh2, Safoora Mazaheri1
1Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Background:
Nephrotoxicity is the major side-effect of cisplatin (CDDP), and it is reported to be gender-related. We evaluated the effects of pomegranate flower extract (PFE) as an antioxidant on CDDP-induced nephrotoxicity in female rats.
Methods:
Twenty-three adult female rats in four groups treated as following. Groups 1 and 2 received PFE at doses of 25 and 50 (mg/kg/day), respectively, for 9 days, and from day 3 on, they also received cisplatin (CDDP) (2.5 mg/kg) daily. Group 3 was treated as group 1 expects saline instead of PFE, and group 4 received PFE (25 mg/kg/day) alone.
Results:
Cisplatin alone increased the serum levels of blood urea nitrogen, creatinine, and nitrite; and kidney tissue damage score and kidney weight. However, PFE not only did not ameliorate the induced nephrotoxicity, but also aggravated renal tissue damage.
Conclusions:
Pomegranate extract as an antioxidant did not ameliorate CDDP-induced nephrotoxicity in female rats.
