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Related Concept Videos

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Multiple sclerosis increases fracture risk: a meta-analysis.

Guixian Dong1, Ning Zhang1, Zhanpo Wu1

  • 1Department of Orthopedics, Harrison International Peace Hospital, Hengshui, Hebei 053000, China.

Biomed Research International
|February 25, 2015
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) significantly increases fracture risk, particularly in women. Certain medications used by MS patients also elevate this risk, highlighting a critical need for preventative strategies.

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Area of Science:

  • Neurology
  • Orthopedics
  • Epidemiology

Background:

  • Previous studies on multiple sclerosis (MS) and fracture risk have yielded conflicting results.
  • A clear understanding of the association between MS and bone health is crucial.

Purpose of the Study:

  • To conduct a meta-analysis to definitively assess the association between multiple sclerosis (MS) and fracture risk.
  • To clarify the ambiguous findings from prior research.

Main Methods:

  • Comprehensive literature searches were performed across PubMed, Embase, and Web of Science databases.
  • Outcome data from relevant articles were pooled to calculate risk ratios (RRs) and 95% confidence intervals (CIs).

Main Results:

  • A statistically significant association was confirmed between MS and an increased risk of fractures.
  • Subgroup analyses revealed heightened risks for tibia, femur, hip, pelvis, vertebrae, and humerus fractures in MS patients.
  • Female MS patients and those using antidepressants, hypnotics/anxiolytics, anticonvulsants, or glucocorticoids exhibited elevated fracture risks.

Conclusions:

  • This meta-analysis provides robust evidence that multiple sclerosis is significantly linked to an increased risk of fractures.
  • Findings underscore the importance of monitoring bone health and considering medication effects in MS management.