Related Experiment Video
Updated: Apr 17, 2026

Investigating Pain-Related Avoidance Behavior using a Robotic Arm-Reaching Paradigm
Published on: October 3, 2020
Learning from PAINful lessons
1Carmot Therapeutics Inc. , 409 Illinois Street, San Francisco, California 94158, United States.
Abstract:
Chemical probes are important both as tools to understand biology and as starting points for drug leads, but not every active molecule makes a good probe; many react nonspecifically with thiols. These promiscuous inhibitors are worse than useless because they can mislead researchers and muddy the literature. Understanding the mechanisms of such compounds can prevent scientists from following false hits down blind alleys.
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