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Updated: Apr 17, 2026

Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures
Published on: March 20, 2019
Dynamics and mechanisms of CNS myelination
Kathryn K Bercury1, Wendy B Macklin1
1Department of Cell and Developmental Biology, University of Colorado School of Medicine, Mail Stop 8108, 12801 East 17(th) Avenue, Aurora, CO 80045, USA.
Abstract:
Vertebrate myelination is an evolutionary advancement essential for motor, sensory, and higher-order cognitive function. CNS myelin, a multilamellar differentiation of the oligodendrocyte plasma membrane, ensheaths axons to facilitate electrical conduction. Myelination is one of the most pivotal cell-cell interactions for normal brain development, involving extensive information exchange between differentiating oligodendrocytes and axons. The molecular mechanisms of myelination are discussed, along with new perspectives on oligodendrocyte plasticity and myelin remodeling of the developing and adult CNS.
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