Jove
Visualize
Contact Us

Related Concept Videos

Inductive Reasoning00:59

Inductive Reasoning

68.0K
Inductive reasoning is a form of logical thinking that uses related observations to arrive at a general conclusion. It is uncertain and operates in degrees to which the conclusions are credible. As such, inductive arguments can be weak or strong, rather than valid or invalid, and conclusions can be used to formulate testable, falsifiable hypotheses.
Inductive reasoning is common in descriptive science. A life scientist makes observations and records them. This data can be qualitative or...
68.0K
Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

11.1K
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
11.1K
Induction01:16

Induction

5.8K
An emf is induced when the magnetic field in a coil is changed by pushing a bar magnet into or out of the coil. emfs of opposite signs are produced by motion in opposite directions, and the directions of emfs are also reversed by reversing poles. The same results are produced if the coil is moved rather than the magnet—it is the relative motion that is important. The faster the motion, the greater the emf. Additionally, there is no emf when the magnet is stationary relative to the coil.
A...
5.8K
Self-Inductance01:24

Self-Inductance

3.1K
Mutual inductance arises when a current in one circuit produces a changing magnetic field that induces an emf in another circuit. On the other hand, self-inductance arises when the current passing through the circuit changes, creating a changing magnetic flux, resulting in inductance in the same circuit.
Consider a circuit connected to an AC source. As the current varies with time, the magnetic flux through the circuit correspondingly changes. Faraday's law tells us that an emf would...
3.1K
Mutual Inductance01:24

Mutual Inductance

3.9K
Inductance is the property of a device that tells us how effectively it induces an emf in another device. In other words, it is a physical quantity that expresses the effectiveness of a given device.
When two circuits carrying time-varying currents are close to one another, the magnetic flux through each circuit varies because of the changing current in the other circuit. Consequently, an emf is induced in each circuit by the changing current in the other. Therefore, this type of emf is called...
3.9K
Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

699
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
699

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polycystic ovary syndrome and breast cancer risk: a systematic review.

European journal of obstetrics, gynecology, and reproductive biology·2026
Same author

Effect of breastfeeding on cardiometabolic risk in patients with polycystic ovary syndrome.

Journal of endocrinological investigation·2026
Same author

Mid-pregnancy serum chemerin levels predict persistence of postpartum hypertension in patients with polycystic ovary syndrome.

European journal of endocrinology·2026
Same author

Age-related female infertility: aetiological mechanisms and evidence-based and experimental interventions.

Reproductive biomedicine online·2026
Same author

Is polycystic ovary syndrome associated with uterine malformations? A systematic review using Bradford Hill's causality framework.

Human reproduction open·2026
Same author

Myo-inositol in reproductive management of women with PCOS: holy grail for medical practice or demon for scientific evidence?

Reproductive biomedicine online·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Feb 14, 2026

Unraveling the Role of Discrete Areas of the Rat Brain in the Regulation of Ovulation through Reversible Inactivation by Tetrodotoxin Microinjections
11:04

Unraveling the Role of Discrete Areas of the Rat Brain in the Regulation of Ovulation through Reversible Inactivation by Tetrodotoxin Microinjections

Published on: September 3, 2020

3.5K

Aromatase inhibitors for ovulation induction.

Stefano Palomba1

  • 1Unit of Reproductive Medicine, ASMN-IRCCS of Reggio Emilia, Italy.

The Journal of Clinical Endocrinology and Metabolism
|February 25, 2015
PubMed
Summary

Aromatase inhibitors like letrozole show promise for treating infertility in women with normogonadotropic anovulation, such as polycystic ovary syndrome (PCOS). This review offers a critical perspective on letrozole as a first-line fertility treatment.

Area of Science:

  • Reproductive Endocrinology
  • Infertility Treatment
  • Pharmacology

Background:

  • Normogonadotropic anovulation, including polycystic ovary syndrome (PCOS), is a significant cause of female infertility.
  • Current treatment paradigms for anovulatory infertility are being re-evaluated.
  • The role of pharmacological interventions in fertility restoration is a key area of research.

Purpose of the Study:

  • To critically evaluate the efficacy and role of aromatase inhibitors, specifically letrozole, as a first-line treatment for infertility in patients with normogonadotropic anovulation.
  • To provide a provocative and personal perspective on the clinical application of letrozole for fertility restoration.
  • To discuss the implications of recent meta-analyses and randomized controlled trials supporting letrozole's use.

Main Methods:

More Related Videos

Assays for Validating Histone Acetyltransferase Inhibitors
09:11

Assays for Validating Histone Acetyltransferase Inhibitors

Published on: August 6, 2020

7.0K
In Vitro Ovule Cultivation for Live-cell Imaging of Zygote Polarization and Embryo Patterning in Arabidopsis thaliana
05:41

In Vitro Ovule Cultivation for Live-cell Imaging of Zygote Polarization and Embryo Patterning in Arabidopsis thaliana

Published on: September 11, 2017

11.5K

Related Experiment Videos

Last Updated: Feb 14, 2026

Unraveling the Role of Discrete Areas of the Rat Brain in the Regulation of Ovulation through Reversible Inactivation by Tetrodotoxin Microinjections
11:04

Unraveling the Role of Discrete Areas of the Rat Brain in the Regulation of Ovulation through Reversible Inactivation by Tetrodotoxin Microinjections

Published on: September 3, 2020

3.5K
Assays for Validating Histone Acetyltransferase Inhibitors
09:11

Assays for Validating Histone Acetyltransferase Inhibitors

Published on: August 6, 2020

7.0K
In Vitro Ovule Cultivation for Live-cell Imaging of Zygote Polarization and Embryo Patterning in Arabidopsis thaliana
05:41

In Vitro Ovule Cultivation for Live-cell Imaging of Zygote Polarization and Embryo Patterning in Arabidopsis thaliana

Published on: September 11, 2017

11.5K
  • Literature review of recent meta-analyses and randomized controlled trials.
  • Critical analysis of existing data on letrozole's effectiveness in treating anovulatory infertility.
  • Synthesis of evidence to support a personal and provocative viewpoint.

Main Results:

  • Evidence suggests aromatase inhibitors, such as letrozole, are effective in restoring ovulation and improving fertility outcomes.
  • Letrozole is increasingly considered a first-line pharmacotherapy for anovulatory infertility, including PCOS.
  • The clinical application warrants a critical and nuanced discussion beyond statistical efficacy.

Conclusions:

  • Letrozole represents a significant advancement in the pharmacotherapy for normogonadotropic anovulatory infertility.
  • A critical appraisal of letrozole's benefits, risks, and long-term implications is essential for optimal patient care.
  • Further research and personalized approaches are needed to refine its position as a first-line fertility treatment.