Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

6.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.6K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

4.2K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
4.2K
Acne Infection01:27

Acne Infection

72
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
72
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.3K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.3K
Pigmentation01:19

Pigmentation

5.0K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
5.0K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

9.0K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
9.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical outcomes of adults accessing acute medical same-day emergency care in the NHS: a retrospective cohort study across two hospitals.

BMJ open·2026
Same author

Varied effectiveness of outpatient rehabilitation interventions in reducing long-term complications following childhood brain tumours: a systematic review.

Frontiers in rehabilitation sciences·2026
Same author

When light turns skin: The eruption of black in Rothko's late paintings (Mark Rothko, Untitled [Black on Gray], 1969-1970).

The Journal of investigative dermatology·2026
Same author

Darier disease-A review highlighting new insights from the Darier Disease International Task Force.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

Applications of Artificial Intelligence (AI) in Breast Cancer Care Delivery and Education: A Scoping Review.

International journal of environmental research and public health·2026
Same author

Description of the Tranquillo Phase 3 Clinical Trial Designs/Study Protocols to Assess Ritlecitinib in Adults and Adolescents with Nonsegmental Vitiligo.

Dermatology and therapy·2026
Same journal

Interventions to prevent or cease electronic cigarette use in children and adolescents.

The Cochrane database of systematic reviews·2026
Same journal

Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

The Cochrane database of systematic reviews·2026
Same journal

Interventions for smoking cessation in inpatient psychiatry settings.

The Cochrane database of systematic reviews·2026
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
See all related articles

Related Experiment Video

Updated: Apr 17, 2026

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

2.2K

Interventions for vitiligo.

Maxine E Whitton1, Mariona Pinart, Jonathan Batchelor

  • 1c/o Cochrane Skin Group, The University of Nottingham, Room A103, King's Meadow Campus, Lenton Lane, Nottingham, UK, NG7 2NR. m40ashley@yahoo.co.uk. Maxine.Whitton@nottingham.ac.uk.

The Cochrane Database of Systematic Reviews
|February 25, 2015
PubMed
Summary
This summary is machine-generated.

This review of vitiligo treatments found combination therapies generally yield better repigmentation results. However, limited data on quality of life and long-term outcomes necessitates further high-quality research.

More Related Videos

Direct Reprogramming of Mouse Fibroblasts into Melanocytes
09:38

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Published on: August 27, 2021

2.6K
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.7K

Related Experiment Videos

Last Updated: Apr 17, 2026

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

2.2K
Direct Reprogramming of Mouse Fibroblasts into Melanocytes
09:38

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Published on: August 27, 2021

2.6K
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.7K

Area of Science:

  • Dermatology
  • Immunology
  • Clinical Trials

Background:

  • Vitiligo is a chronic skin disorder causing patchy skin depigmentation, affecting approximately 1% of the global population.
  • It can manifest in generalized or segmental forms, often appearing before age 20, with some experiencing itching prior to new patch development.
  • While treatments exist to restore pigment, a definitive cure for vitiligo remains elusive.

Purpose of the Study:

  • To comprehensively assess the efficacy and effects of all therapeutic interventions utilized in the management of vitiligo.
  • To synthesize findings from randomized controlled trials (RCTs) evaluating vitiligo treatments.

Main Methods:

  • An updated systematic review of multiple databases (Cochrane Skin Group, CENTRAL, MEDLINE, Embase, AMED, PsycINFO, CINAHL, LILACS) up to October 2013.
  • Inclusion of randomized controlled trials (RCTs) assessing vitiligo treatments, with independent eligibility assessment and data extraction by two authors.
  • Analysis focused on primary outcomes: quality of life, >75% repigmentation, and adverse effects, alongside secondary outcomes like cessation of spread and long-term permanence.

Main Results:

  • The review included 96 studies with 4512 participants; most studies had small sample sizes (<50 participants).
  • Combination therapies generally showed superior repigmentation results compared to monotherapies, including calcipotriol plus PUVA and oral minipulse of prednisolone (OMP) plus narrowband UVB (NB-UVB).
  • Narrowband UVB (NB-UVB) showed a non-significant trend towards better >75% repigmentation than PUVA and reported fewer adverse effects like nausea and erythema.

Conclusions:

  • Existing vitiligo therapies show some evidence of efficacy, but study heterogeneity in design and outcome measurement limits definitive conclusions.
  • A significant lack of quality of life assessments and data on the long-term permanence of repigmentation was noted.
  • High-quality randomized trials with standardized measures, including quality of life and long-term follow-up, are crucial for advancing vitiligo management.