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Updated: Apr 17, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Meta-analysis and association of brain-derived neurotrophic factor (BDNF) gene with obsessive-compulsive disorder
Gwyneth Zai1, Clement C Zai, Paul D Arnold
1aNeurogenetics Section, Centre for Addiction and Mental Health bDepartment of Psychiatry and Institute of Medical Science, University of Toronto cDepartment of Psychiatry and Program in Genetics and Genome Biology, Hospital for Sick Children dFrederick W. Thompson Anxiety Disorders Centre and Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Abstract:
Obsessive-compulsive disorder (OCD) is a severe psychiatric condition with a clear genetic component (Nicolini et al., 2009) in which neurodevelopmental mechanisms may be etiologically important. Brain-derived neurotrophic factor (BDNF) is an interesting candidate for molecular analysis in OCD on the basis of potential functional relevance, positive association studies, and reported interaction between this gene and other neurotransmitters implicated in this disorder.
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