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Related Concept Videos

Computed Tomography01:10

Computed Tomography

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
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Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
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Updated: Apr 17, 2026

Using Synchrotron Radiation Microtomography to Investigate Multi-scale Three-dimensional Microelectronic Packages
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Micro Computer Tomography for medical device and pharmaceutical packaging analysis.

Florine Hindelang1, Raphael Zurbach1, Yves Roggo1

  • 1Complaint and Counterfeit Department, Quality Control for Commercial Bulk Products, F. Hoffmann-La Roche Ltd, Wurmisweg, CH-4303 Kaiseraugst, Switzerland.

Journal of Pharmaceutical and Biomedical Analysis
|February 25, 2015
PubMed
Summary
This summary is machine-generated.

Micro Computer Tomography (Micro CT) enhances quality control in medical device and pharmaceutical manufacturing. This non-destructive technique verifies product integrity, performs precise measurements, and detects defects.

Keywords:
3D imagingDefect detectionMedical deviceQuality controlX-ray microtomography

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Area of Science:

  • Materials Science
  • Medical Imaging
  • Manufacturing Engineering

Background:

  • Biomedical and pharmaceutical manufacturing face intense global competition, necessitating continuous quality and safety improvements.
  • Technological advancements are crucial for enhancing the reliability and safety of medical devices and pharmaceutical products.
  • Traditional quality control methods can be time-consuming and may not offer comprehensive analysis.

Purpose of the Study:

  • To explore the applications of Micro Computer Tomography (Micro CT) in the analysis of medical devices and pharmaceutical packaging.
  • To demonstrate the capability of Micro CT in non-destructively assessing product quality, integrity, and detecting defects.
  • To highlight Micro CT as a valuable tool for quality improvement in manufacturing processes.

Main Methods:

  • Utilizing Micro Computer Tomography (Micro CT) for high-resolution, non-destructive imaging of various medical device and pharmaceutical packaging samples.
  • Performing detailed analysis of the acquired Micro CT data to assess structural integrity, dimensional accuracy, and identify internal/external flaws.
  • Comparing Micro CT findings with established quality control parameters.

Main Results:

  • Micro CT successfully provided detailed internal and external views of the investigated samples.
  • The technique effectively verified the integrity of medical devices and pharmaceutical packaging.
  • Micro CT enabled accurate dimensional measurements and reliable detection of defects without damaging the products.
  • Suitability of Micro CT for non-destructive quality assessment was confirmed.

Conclusions:

  • Micro Computer Tomography is a highly suitable technology for the non-destructive analysis of medical devices and pharmaceutical packaging.
  • Micro CT facilitates enhanced quality control by enabling precise defect detection, integrity verification, and accurate measurements.
  • The adoption of Micro CT can significantly contribute to improving the overall quality, safety, and reliability in these manufacturing sectors.