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Simultaneous recording of presynaptic spikes and excitatory postsynaptic potentials from monosynaptically connected
S Sawada1, H Kamiya, C Yamamoto
1Department of Physiology, Faculty of Medicine, Kanazawa University, Japan.
Neuroscience Letters
|August 14, 1989
Abstract:
A technique has been devised to activate single granule cells in the hippocampus, and to record simultaneously spikes from the particular granule cell and excitatory postsynaptic potentials from a monosynaptically connected CA3 neuron. The unitary excitatory postsynaptic potentials (EPSPs) sustained for long observation periods, and increased in size with increases in stimulus frequency and in external Ca2+ concentration. This technique may be useful for quantal analysis of transmission through the synapse between mossy fibers and CA3 neurons.