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P-glycoprotein in autoimmune rheumatic diseases.

M García-Carrasco1, C Mendoza-Pinto1, S Macias Díaz2

  • 1Systemic Autoimmune Diseases Research Unit, Hospital General Regional No. 36, Instituto Mexicano del Seguro Social, Puebla, Mexico; Department of Immunology and Rheumatology, Medicine School, Benemérita Universidad Autónoma dePuebla, Puebla, Mexico.

Autoimmunity Reviews
|February 26, 2015
PubMed
Summary

P-glycoprotein (Pgp), a transporter protein, plays a role in drug resistance and autoimmune diseases. MDR-1 gene polymorphisms influence Pgp function, impacting conditions like inflammatory bowel disease and cancer.

Keywords:
Flow cytometryGlucocorticoidsIneffective therapyMethotrexateP-glycoproteinPsoriatic arthritisRheumatoid arthritisSystemic lupus erythematosus

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