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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
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Fragmented QRS complex is a diagnostic tool in patients with left ventricular diastolic dysfunction
Yoshiro Onoue1, Yasuhiro Izumiya2, Shinsuke Hanatani1
1Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan.
Heart and Vessels
|February 26, 2015
Summary
Fragmented QRS complex (fQRS) on ECG indicates more severe left ventricular diastolic dysfunction (LVDD). fQRS can help differentiate heart failure with preserved ejection fraction (HFpEF) in LVDD patients.
Area of Science:
- Cardiology
- Electrophysiology
Background:
- Fragmented QRS complex (fQRS) on ECG correlates with myocardial fibrosis and scar.
- Interstitial fibrosis is a key feature of left ventricular diastolic dysfunction (LVDD).
- The clinical significance of fQRS in LVDD patients is not well-established.
Purpose of the Study:
- To investigate the association between fQRS and LVDD severity.
- To determine if fQRS can differentiate heart failure with preserved ejection fraction (HFpEF) from LVDD.
Main Methods:
- Analysis of 12-lead ECGs from 239 LVDD patients.
- Classification of patients into fQRS (n=88) and non-fQRS (n=151) groups.
- Comparison of clinical parameters and biomarkers between groups.
Main Results:
- Higher prevalence of heart failure in the fQRS group.
- Significantly elevated B-type natriuretic peptide (BNP) and high-sensitive troponin T levels in the fQRS group.
- fQRS identified as an independent indicator for HFpEF in multivariate analysis.
Conclusions:
- fQRS presence is linked to increased disease severity in LVDD.
- fQRS, alongside BNP, serves as an independent predictor for differentiating HFpEF in LVDD patients.
- fQRS may be a valuable additional ECG parameter for clinical assessment of LVDD.
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