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Updated: Apr 17, 2026

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Published on: June 2, 2014
Association between TNFSF10 polymorphism and migraine susceptibility in a Chinese population
Shasha Jia1, Wanli Dong2, Xianju Zhou1
1Department of Neurology, Laboratory of Neurological Diseases, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.
Objective:
To investigate the correlation between migraine in a Chinese population and a 4 base pair (GAGT) insertion/deletion polymorphism (rs35975099) localized near the 3' end of the tumour necrosis factor superfamily 10 gene, TNFSF10.
Methods:
Ethnically Han Chinese patients with migraine and healthy control subjects were recruited. TNFSF10 genotype and allele frequencies were determined via polymerase chain reaction and polyacrylamide gel electrophoresis.
Results:
Rs35975099 was in Harvey-Weinberg equilibrium in patients with migraine (n = 269) and control subjects (n = 374). There were no significant relationships between allele or genotype frequency and migraine.
Conclusion:
There was no functional significance of the TNFSF10 gene polymorphism rs35975099 in migraine pathogenesis.
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