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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Pro: cardiovascular calcifications are clinically relevant.

Jordi Bover1, Pieter Evenepoel2, Pablo Ureña-Torres3

  • 1Fundació Puigvert, Department of Nephrology, IIB Sant Pau, RedinRen, Barcelona, Catalonia, Spain.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|February 26, 2015
PubMed
Summary
This summary is machine-generated.

Screening for cardiovascular calcification in chronic kidney disease (CKD) patients with mineral and bone disorders (MBDs) may help stratify risk. While evidence is limited, this approach could guide therapy and improve outcomes.

Keywords:
chronic kidney diseasedialysishyperphosphataemiavascular calcification

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Area of Science:

  • Nephrology
  • Cardiology
  • Mineral and Bone Disorders

Background:

  • Mineral and bone disorders (MBDs) are linked to high cardiovascular (CV) disease rates in chronic kidney disease (CKD).
  • Cardiovascular calcification is a key feature of CKD-MBD, prompting debate on clinical screening.
  • The modifiability and reversibility of vascular calcification in CKD are critical considerations.

Purpose of the Study:

  • To evaluate the role of screening for cardiovascular calcification in CKD patients.
  • To discuss the implications of new treatments for CKD-MBD on cardiovascular calcification progression.
  • To explore the potential of personalized medicine in managing CV risk in CKD.

Main Methods:

  • Review of experimental and clinical evidence on the progression of CV calcification.
  • Analysis of current treatment options for CKD-MBD, including calcium-free phosphate binders and calcimimetics.
  • Discussion of the limitations of existing hard outcome data.

Main Results:

  • Experimental and clinical data suggest that CV calcification progression may be attenuated with new therapies.
  • Current hard outcome data are limited and have yielded inconclusive results regarding treatment efficacy.
  • The potential for improved outcomes and reduced healthcare costs through targeted screening and therapy is hypothesized.

Conclusions:

  • Screening for CV calcification in selected CKD individuals is considered reasonable pending further studies.
  • This approach may aid in stratifying CV risk and guiding therapeutic interventions.
  • Personalized medicine strategies incorporating CV calcification screening could ultimately enhance patient outcomes and reduce health costs.