Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Teeth01:15

Teeth

2.4K
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
2.4K
Tooth Anatomy01:21

Tooth Anatomy

3.0K
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
3.0K
Pleiotropy01:33

Pleiotropy

44.3K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
44.3K
Incomplete Dominance01:43

Incomplete Dominance

32.9K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
32.9K
Genetic Material01:20

Genetic Material

4.0K
Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.
4.0K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

39.2K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
39.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential and Combined Therapeutic Effects of Mesenchymal Stem Cells and Glutathione on Methotrexate-Induced Mucositis.

Journal of biochemical and molecular toxicology·2026
Same author

Genotype-phenotype correlations in retinitis pigmentosa: structural and vascular insights using OCT and OCTA.

International journal of retina and vitreous·2026
Same author

The genetic landscape of childhood-onset dystonia in a nationwide Turkish cohort: Clinical spectrum, molecular diagnostics, and therapeutic implications.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2026
Same author

Genotype-Phenotype Correlations in Phenylketonuria and Hyperphenylalaninemia: A Single-Center Study.

Pediatrics international : official journal of the Japan Pediatric Society·2026
Same author

Corticotomy-assisted application of different miniplates and intermaxillary elastics : Comparison of the effectiveness after growth spurt in individuals with skeletal class III malocclusion.

Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie·2026
Same author

The impact of different rapid palatal expansion appliances on sleep, nasal airway resistance, and dentoskeletal/dentoalveolar characteristics: a prospective, randomized controlled trial.

European journal of orthodontics·2026

Related Experiment Video

Updated: Apr 17, 2026

Isolation and Culture of Dental Epithelial Stem Cells from the Adult Mouse Incisor
08:14

Isolation and Culture of Dental Epithelial Stem Cells from the Adult Mouse Incisor

Published on: May 1, 2014

16.1K

Genetic background of supernumerary teeth.

Aslı Subasioglu1, Selcuk Savas2, Ebru Kucukyilmaz2

  • 1Department of Medical Genetics, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkiye.

European Journal of Dentistry
|February 26, 2015
PubMed
Summary

Supernumerary teeth (ST), an excess of teeth, are linked to various genetic disorders. Early diagnosis of ST aids in managing these congenital conditions and planning long-term patient care.

Keywords:
Dental anomaliesgenetic syndromessupernumerary teeth

More Related Videos

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
07:26

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

Published on: August 22, 2022

2.1K
The Slice Culture Method for Following Development of Tooth Germs In Explant Culture
07:47

The Slice Culture Method for Following Development of Tooth Germs In Explant Culture

Published on: November 13, 2013

14.8K

Related Experiment Videos

Last Updated: Apr 17, 2026

Isolation and Culture of Dental Epithelial Stem Cells from the Adult Mouse Incisor
08:14

Isolation and Culture of Dental Epithelial Stem Cells from the Adult Mouse Incisor

Published on: May 1, 2014

16.1K
Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
07:26

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

Published on: August 22, 2022

2.1K
The Slice Culture Method for Following Development of Tooth Germs In Explant Culture
07:47

The Slice Culture Method for Following Development of Tooth Germs In Explant Culture

Published on: November 13, 2013

14.8K

Area of Science:

  • Odontostomatology
  • Genetics
  • Pediatric Dentistry

Background:

  • Supernumerary teeth (ST) represent an odontostomatologic anomaly involving an excess number of teeth beyond the normal dental formula.
  • ST are frequently associated with congenital genetic disorders, including Gardner's syndrome, cleidocranial dysostosis, and cleft lip and palate.

Purpose of the Study:

  • To review and discuss the genetic syndromes associated with supernumerary teeth.
  • To highlight the importance of ST as a potential indicator for early diagnosis of underlying genetic conditions.

Main Methods:

  • Literature review of genetic syndromes associated with supernumerary teeth.
  • Synthesis of information regarding the clinical significance and diagnostic implications of ST.

Main Results:

  • Identified common genetic disorders linked to ST, such as Gardner's syndrome and cleidocranial dysostosis.
  • Cataloged less common associated syndromes including Fabry Disease, Ellis-van Creveld syndrome, Nance-Horan syndrome, Rubinstein-Taybi Syndrome, and Trico-Rhino-Phalangeal syndrome.

Conclusions:

  • Supernumerary teeth can serve as a crucial diagnostic clue for various genetic disorders.
  • Early detection of ST facilitates timely diagnosis, appropriate patient management, and informed decisions regarding long-term medical care.