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Relation of red cell distribution width to contrast-induced acute kidney injury in patients undergoing a primary

Fatih Akin1, Omer Celik, Ibrahim Altun

  • 1aDepartment of Cardiology, Muğla Sıtkı Kocman University School of Medicine, Muğla bDepartment of Cardiology, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Education and Research Hospital cDepartment of Cardiology, Bağcılar Education and Research Hospital dDepartment of Cardiology, Acıbadem University School of Medicine, Istanbul, Turkey.

Coronary Artery Disease
|February 26, 2015
PubMed

Insights

Red blood cell distribution width (RDW) can help predict contrast-induced acute kidney injury (CI-AKI) in ST-segment-elevation myocardial infarction (STEMI) patients. This inexpensive marker aids in CI-AKI risk stratification after primary percutaneous coronary intervention.

Area of Science:

  • Cardiology
  • Nephrology
  • Laboratory Medicine

Background:

  • Contrast-induced acute kidney injury (CI-AKI) is a complication in patients undergoing percutaneous coronary intervention (PCI) for ST-segment-elevation myocardial infarction (STEMI).
  • Predictive markers for CI-AKI are crucial for risk stratification and patient management.

Purpose of the Study:

  • To evaluate the utility of preprocedural red cell distribution width (RDW) in predicting CI-AKI.
  • To assess RDW as a potential biomarker for CI-AKI risk in STEMI patients undergoing primary PCI.

Main Methods:

  • A cohort of 630 consecutive STEMI patients undergoing primary PCI was analyzed.
  • Preprocedural RDW and other laboratory parameters were measured.
  • Multivariate logistic regression was used to identify independent predictors of CI-AKI.

Main Results:

  • CI-AKI developed in 12.5% of patients.
  • Higher preprocedural RDW was significantly associated with CI-AKI development (P=0.005).
  • Left ventricular ejection fraction, estimated glomerular filtration rate, contrast volume, and RDW were independent predictors of CI-AKI.

Conclusions:

  • Preprocedural RDW is an independent predictor of CI-AKI in STEMI patients undergoing primary PCI.
  • RDW is an inexpensive and easily measurable marker that can aid in CI-AKI risk stratification.
  • The findings suggest RDW's utility in identifying patients at higher risk for CI-AKI.
Abstract

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