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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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Synthesis of trifluoromethyl-containing vicinal diamines by asymmetric decarboxylative mannich addition reactions
Lingmin Wu1, Chen Xie1, Haibo Mei1
1†School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, China.
Abstract:
Herein is reported a study of asymmetric decarboxylative Mannich addition reactions between (Ss)-N-t-butylsulfinyl-3,3,3-trifluoroacetaldimine and Schiff bases derived from various aldehydes and lithium 2,2-diphenylglycinate. These reactions proceed with excellent diastereoselectivities and good chemical yields, providing a practical method for preparation of trifluoromethyl-containing vicinal diamines. The procedures can be conducted under convenient conditions, rendering this approach of high synthetic value.
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