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Updated: Apr 17, 2026

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
Published on: March 28, 2025
mTOR and metabolic regulation of conventional and regulatory T cells
Chaohong Liu1, Nicole M Chapman1, Peer W F Karmaus1
1Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Abstract:
mTOR signaling links bioenergetic and biosynthetic metabolism to immune responses. mTOR is activated by diverse upstream stimuli, including immune signals, growth factors, and nutrients. Recent studies highlight crucial roles of mTOR signaling in immune functions mediated by conventional T cells and Tregs In this review, we discuss the regulation of mTOR signaling in T cells and the functional impacts of mTOR and metabolic pathways on T cell-mediated immune responses, with a particular focus on the differentiation and function of Tregs.
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