Related Experiment Video
Updated: Sep 12, 2026

Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations
Published on: February 2, 2024
Treatment of infantile spasms with methysergide and alpha-methylparatyrosine
R A Hrachovy1, J D Frost, D G Glaze
1Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.
Abstract:
Twenty-four newly diagnosed and previously untreated infantile spasm patients were treated for 3 weeks with either methysergide (12 patients) or alpha-methylparatyrosine (12 patients). Response to therapy was determined objectively with 24-h polygraphic/video monitoring techniques and was defined as cessation of spasms and disappearance of the hypsarrhythmic EEG pattern. Two (17%) of the patients treated with alpha-methylparatyrosine responded to therapy, and one (8%) of the methysergide-treated group showed a response.
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