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PARK2/Parkin becomes critical when DNM1L/Drp1 is absent
Madhuparna Roy1, Yusuke Kageyama, Miho Iijima
1a Department of Cell Biology ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
Abstract:
Maintaining mitochondrial dynamics and proper execution of mitophagy is crucial for sustaining cellular health. Defects in these processes have been linked to cardiovascular diseases and neurodegeneration. In a recent publication, we reported that the mitochondrial division dynamin protein DNM1L/Drp1 and the E3 ubiquitin ligase PARK2/Parkin work in a synergistic manner to maintain mitochondrial function and structural integrity in the mouse heart and brain.
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