Related Experiment Videos
Localization of a human brain sodium channel gene (SCN2A) to chromosome 2
1Department of Biochemistry, Oregon Health Sciences University, Portland 97201.
Genomics
|August 1, 1989
Abstract:
A DNA probe derived from a human genomic library has been used to localize on human chromosomes a gene coding for the alpha-subunit of the brain type II sodium channel (SCN2A). Hybridization of the probe to Southern blots made with DNAs from a rodent-human somatic cell hybrid panel indicates localization to the long arm of human chromosome 2. In situ hybridization to metaphase chromosomes confirms this assignment and indicates regional localization to 2q21-q33. The probe also reveals a frequent two-allele HaeIII RFLP.