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Updated: Apr 16, 2026

Merkel Cell Polyomavirus Infection and Detection
Published on: February 7, 2019
Spontaneous regression and recurrence of stage III Merkel cell carcinoma
Sandra Catharina Petronella Jansen1, Christine P M Groeneveld-Haenen2, Paul J J M Klinkhamer3
1Department of Surgery, Maxima Medical Centre, Veldhoven, Noord-Brabant, The Netherlands.
Abstract:
Merkel cell carcinoma (MCC) is a malignant neuroendocrine carcinoma originating in the skin. It is typically aggressive with a tendency to recur locally and metastasise. There have been several case reports about spontaneous regression of MCC over the past years, but to the best of our knowledge this is the first case of a regional lymph node metastasised MCC with complete spontaneous regression and recurrence. In addition, the primary tumour has an unusual localisation on the foot.
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