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Published on: September 4, 2016
Chromium content in the human hip joint tissues
Barbara Brodziak-Dopierała1, Jerzy Kwapuliński2, Krzysztof Sobczyk3
1School of Pharmacy with the Division of Laboratory Medicine, Department of Toxicology, Medical University of Silesia, 4 Jagiellonska, Str. 41-200 Sosnowiec, Poland.
Insights
This study measured chromium levels in hip tissues, finding the highest concentration in cancellous bone and the lowest in the joint capsule. Chromium content differed significantly between osteoarthritis and fracture patients.
Area of Science:
- Biochemistry
- Orthopedics
- Trace Elements
Background:
- Chromium is essential for human health, but its role in bone tissue is not well understood.
- Understanding chromium distribution in hip tissues is crucial for osseous health research.
Purpose of the Study:
- To quantify chromium content in various hip joint tissues.
- To investigate potential differences in chromium levels related to hip joint conditions.
Main Methods:
- Analyzed 91 hip joint samples (66 female, 25 male) using Atomic Absorption Spectrometry (AAS).
- Tissues were anatomically separated, and chromium content was measured.
- Statistical analysis employed the U Mann-Whitney non-parametric test (P≤0.05).
Main Results:
- Highest chromium levels were found in cancellous bone (17.86 µg/g), followed by cancellous bone fragments (5.95 µg/g).
- Lowest chromium content was observed in the joint capsule (1.28 µg/g).
- Chromium levels were higher in patients with fractures (12.59 µg/g) compared to those with osteoarthritis (7.04 µg/g).
Conclusions:
- Cancellous bone exhibits the highest chromium concentration in hip joint tissues.
- Joint capsule has the lowest chromium concentration.
- Significant differences in chromium content exist between hip osteoarthritis and femoral neck fracture patients.
Objective:
Chromium has many important functions in the human body. For the osseous tissue, its role has not been clearly defined. This study was aimed at determining chromium content in hip joint tissues.
Methods:
A total of 91 hip joint samples were taken in this study, including 66 from females and 25 from males. The sample tissues were separated according to their anatomical parts. The chromium content was determined by the AAS method. The statistical analysis was performed with U Mann-Whitney's non-parametric test, P≤0.05.
Results:
The overall chromium content in tissues of the hip joint in the study subjects was as follows: 5.73 µg/g in the articular cartilage, 5.33 µg/g in the cortical bone, 17.86 µg/g in the cancellous bone, 5.95 µg/g in the fragment of the cancellous bone from the intertrochanteric region, and 1.28 µg/g in the joint capsule. The chromium contents were observed in 2 group patients, it was 7.04 µg/g in people with osteoarthritis and 12.59 µg/g in people with fractures.
Conclusion:
The observed chromium content was highest in the cancellous bone and the lowest in the joint capsule. Chromium content was significantly different between the people with hip joint osteoarthritis and the people with femoral neck fractures.
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