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Updated: Apr 16, 2026
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A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
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PRIMARY ADRENAL LYMPHOMA: A SINGLE-CENTER EXPERIENCE.
Summary
Primary adrenal lymphoma (PAL) often presents as bilateral adrenal masses, potentially causing adrenal insufficiency (AI). Diffuse large B-cell lymphoma (DLBCL) is common, and long-term prognosis remains poor despite treatment.
Area of Science:
- Oncology
- Endocrinology
- Pathology
Background:
- Primary adrenal lymphoma (PAL) is a rare malignancy.
- Adrenal masses can be challenging to diagnose.
- Understanding PAL's characteristics is crucial for timely management.
Purpose of the Study:
- To detail the clinical, biochemical, and imaging features of primary adrenal lymphoma (PAL).
- To evaluate treatment outcomes for patients with PAL.
- To highlight the importance of considering PAL in the differential diagnosis of adrenal masses.
Main Methods:
- Retrospective analysis of 7 patients diagnosed with PAL.
- Data collected included clinical presentation, biochemistry, and imaging.
- Treatment modalities and outcomes were reviewed.
Main Results:
- Median age was 48 years; male predominance (6:1).
- Bilateral adrenal involvement occurred in 58%, with 75% of these patients developing adrenal insufficiency (AI).
- Diffuse large B-cell lymphoma (DLBCL) was the most common type (85%); 1-year survival was 57%.
Conclusions:
- Primary adrenal lymphoma (PAL) should be considered in bilateral adrenal masses, especially with adrenal insufficiency (AI).
- Diffuse large B-cell lymphoma (DLBCL) is the predominant subtype.
- Long-term prognosis for PAL remains poor despite current treatment strategies.
