Related Experiment Video
Updated: Apr 16, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Chronic hepatitis B in children with or without malignancies: a 13-year follow-up
Merve Usta1, Nafiye Urgancı1, Zeynep Yıldız Yıldırmak1
1Merve Usta, Nafiye Urgancı, Department of Pediatric Gastroenterology, Sisli Hamidiye Etfal Education and Research Hospital, Istanbul 34377, Turkey.
Aim:
To evaluate the outcome of chronic hepatitis B (CHB) in children with or without malignancies.
Methods:
Twenty four children (15 boys and 9 girls) with malignancies, followed up by the pediatric gastroenterology outpatient clinic for CHB between January 2000 and December 2013, were enrolled in the study (Group 1). Group 2 was formed with twenty five children (11 girls and 14 boys) diagnosed with CHB without malignancies. The data from the patients' records were compared between the two groups.
Results:
Hepatitis B e antigen (HBeAg)/antiHBe seroconversion was observed in 3 patients (12.5%) in group 1 and 15 patients (60%) in group 2, with annual seroconversion rates of 1.61% and 16.6%, respectively, and the difference was significant (P<0.01). One patient (6.6%) in Group 1 and 9 patients (53%) in Group 2 showed HBeAg/antiHBe seroconversion after treatment and the difference between the two groups was significant (P<0.06) Loss of hepatitis B surface antigen was observed in one patient in each of group 1 and 2. No clinical, laboratory and imaging findings of liver disease were observed in any of the patients at the end of the study.
Conclusion:
HBeAg/antiHBe seroconversion rate was lower in patients who had recovered from cancer.
More Related Videos
Related Concept Videos
Hepatitis
Cytomegalovirus Disease
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Pharmacokinetics in Pediatric Patients: Drug Excretion
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

