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Updated: Apr 16, 2026
09:09
A Murine Model of Cervical Spinal Cord Injury to Study Post-lesional Respiratory Neuroplasticity
Published on: May 28, 2014
14.1K
Spinal metaplasticity in respiratory motor control.
Daryl P Fields1, Gordon S Mitchell1
1Department of Comparative Biosciences, University of Wisconsin-Madison Madison, WI, USA.
Frontiers in Neural Circuits
|February 27, 2015
Summary
Respiratory metaplasticity, the brain
Area of Science:
- Neuroscience
- Respiratory Control
- Motor Plasticity
Background:
- The neural control of breathing exhibits plasticity.
- Metaplasticity, or
- Purpose_of_the_Study
Purpose of the Study:
- Investigate respiratory metaplasticity.
- Understand mechanisms of spinal plasticity and metaplasticity in phrenic motor output.
- Explore harnessing metaplasticity for clinical applications.
Main Methods:
- Review of cellular mechanisms.
- Analysis of respiratory motor plasticity and metaplasticity.
- Pre-conditioning with intermittent hypoxia.
Main Results:
- Respiratory motor control demonstrates metaplasticity.
- Intermittent hypoxia is a key pre-conditioning factor.
- Similar mechanisms apply to limb motor networks.
Conclusions:
- Understanding respiratory metaplasticity is crucial for treating breathing disorders.
- Mechanisms of respiratory metaplasticity can restore motor function after spinal injury.
- Harnessing metaplasticity offers therapeutic potential for neuromuscular diseases.
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