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Related Concept Videos

Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

377
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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Related Experiment Video

Updated: Apr 16, 2026

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
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Early Outcome of Prostate Intensity Modulated Radiation Therapy (IMRT) Incorporating a Simultaneous Intra-Prostatic

Michael H Schild1, Steven E Schild1, William W Wong1

  • 1Department of Radiation Oncology, Mayo Clinic Arizona, Scottsdale 85259, USA.

OMICS Journal of Radiology
|February 27, 2015
PubMed
Summary
This summary is machine-generated.

Intensity modulated radiotherapy (IMRT) with MRI-directed boosts is a feasible and well-tolerated treatment for prostate cancer. This approach improves outcomes by targeting the malignancy with higher doses, minimizing toxicity to surrounding organs.

Keywords:
Biochemical disease controlImage guided radiation therapyMRI directed boostSimultaneous intra-prostatic boostToxicity survival

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Area of Science:

  • Radiation Oncology
  • Urologic Oncology
  • Medical Imaging

Background:

  • Prostate cancer treatment often involves radiotherapy.
  • Optimizing dose delivery to the tumor while sparing organs at risk is crucial.
  • Magnetic Resonance Imaging (MRI) can improve tumor targeting in radiotherapy.

Purpose of the Study:

  • To assess the feasibility and outcomes of intensity modulated radiotherapy (IMRT) for prostate cancer.
  • To evaluate the efficacy of an MRI-directed simultaneous intra-prostatic boost (SIB).
  • To determine the toxicity profile of this treatment approach.

Main Methods:

  • Seventy-eight men with localized prostate cancer received IMRT.
  • A dose of 77.4Gy in 43 fractions was delivered to the entire prostate.
  • An MRI-identified boost of 83Gy was administered to the malignancy, or 81Gy to the posterior prostate if no neoplasm was detected.
  • Androgen Deprivation Therapy (ADT) was given to 41% of patients.

Main Results:

  • Three-year rates for biochemical control, local control, distant control, and survival were 92%, 98%, 95%, and 95%, respectively.
  • Grade 1-2 toxicities were common, with only 2 patients experiencing grade 3 toxicity (strictures, successfully treated).
  • The technique allowed for dose escalation to the tumor without increasing rectal and bladder doses.

Conclusions:

  • IMRT incorporating an MRI-directed intra-prostatic boost is a feasible and well-tolerated treatment for prostate cancer.
  • This technique demonstrates a favorable therapeutic index by escalating the dose to the malignancy.
  • The findings support the use of MRI-guided boosts to enhance prostate cancer radiotherapy outcomes.