Related Experiment Videos
Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain
D G Wilkinson1, S Bhatt, M Cook
1Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, London, UK.
Nature
|October 5, 1989
Abstract:
The vertebrate hindbrain develops in a segmental pattern, with distinctive groups of neurons originating from different segments. We report here that members of the Hox-2 cluster of murine homoeobox genes are expressed in segment-specific patterns in the developing hindbrain, with successive genes having boundaries at two-segment intervals. These data indicate that Hox genes specify segment phenotype, a role analogous to that of their Drosophila homologues.