Related Experiment Video
Updated: Apr 16, 2026

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
Published on: May 18, 2022
Tipping the metabolic scales towards increased longevity in mammals
Celine E Riera1, Andrew Dillin1
1Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA and Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.
Abstract:
A hallmark of ageing is dysfunction in nutrient signalling pathways that regulate glucose homeostasis, negatively affecting whole-body energy metabolism and ultimately increasing the organism's susceptibility to disease. Maintenance of insulin sensitivity depends on functional mitochondrial networks, but is compromised by alterations in mitochondrial energy metabolism during ageing. Here we discuss metabolic paradigms that influence mammalian longevity, and highlight recent advances in identifying fundamental signalling pathways that influence metabolic health and ageing through mitochondrial perturbations.
Related Concept Videos
Metabolic Rate
The Basal Metabolic Rate (BMR) measures the energy expended at rest.
Several factors influence...
Mitochondria
Energy Budgets
Evolution of New Traits in Microbes
PI3K/mTOR/AKT Signaling Pathway

