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Related Concept Videos

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Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
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Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
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Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
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Related Experiment Video

Updated: Apr 16, 2026

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat
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Child/Adolescent anxiety multimodal study: evaluating safety.

Moira A Rynn1, John T Walkup2, Scott N Compton3

  • 1Columbia University Medical Center (CUMC)/New York State Psychiatric Institute, New York.

Journal of the American Academy of Child and Adolescent Psychiatry
|February 28, 2015
PubMed
Summary

Adverse events (AEs) were evaluated in children and adolescents with anxiety disorders. While selective serotonin reuptake inhibitor (SSRI) treatment showed good tolerability, psychiatric AEs were more common in younger children.

Keywords:
adverse eventsanxietyselective serotonin reuptake inhibitors

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Area of Science:

  • Child and Adolescent Psychiatry
  • Clinical Psychology
  • Pharmacology

Background:

  • Anxiety disorders are prevalent in children and adolescents.
  • Multimodal treatment approaches are increasingly utilized.
  • Understanding adverse event profiles is crucial for treatment selection.

Purpose of the Study:

  • To assess adverse event (AE) frequency across four treatment arms in the Child/Adolescent Anxiety Multimodal Study (CAMS).
  • To compare AE frequency between pediatric and adolescent patient groups.
  • To evaluate the safety and tolerability of cognitive-behavioral therapy (CBT), sertraline (SRT), combination therapy (COMB), and placebo (PBO).

Main Methods:

  • Randomized controlled trial (RCT) with a 2:2:2:1 allocation ratio.
  • Participants (ages 7-17) diagnosed with separation anxiety disorder, generalized anxiety disorder, or social phobia.
  • AE data collected via standardized inquiry and Physical Symptom Checklist (PSC).

Main Results:

  • No significant differences in overall physical or psychiatric AEs between double-blinded sertraline (SRT) and placebo (PBO).
  • Higher rates of physical AEs in the SRT-alone group compared to cognitive-behavioral therapy (CBT) and combination (COMB) therapy.
  • Increased psychiatric AEs observed in younger children (≤12 years) across all treatment arms.

Conclusions:

  • Selective serotonin reuptake inhibitor (SSRI) treatment is generally well-tolerated for pediatric anxiety disorders.
  • Few specific AE differences were noted between treatment conditions.
  • Enhanced monitoring for psychiatric AEs is recommended for children aged 12 years and younger.