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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Gene Therapy00:59

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
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Augmented adenovirus transduction of murine T lymphocytes utilizing a bi-specific protein targeting murine interleukin 2 receptor.

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Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
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Gene therapy for radioprotection.

W H Everett1, D T Curiel1

  • 1Division of Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine in St Louis, St Louis, MO, USA.

Cancer Gene Therapy
|February 28, 2015
PubMed
Summary
This summary is machine-generated.

Gene therapy offers a promising approach to radioprotection, aiming to shield normal tissues from radiation damage during cancer treatment. Future advancements in delivery systems are expected to significantly improve its effectiveness in minimizing side effects.

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Molecular Therapy

Background:

  • Radiation therapy is a cornerstone of cancer treatment, utilized by over half of all patients.
  • Despite therapeutic advancements, off-target radiation exposure can cause normal tissue damage and side effects.
  • Radioprotectors are crucial for mitigating radiation-induced damage to healthy tissues.

Purpose of the Study:

  • To explore the potential of gene therapy as a novel strategy for radioprotection.
  • To highlight the advantages of gene therapy in targeting and modulating gene expression for tissue protection.
  • To identify future research directions for enhancing gene therapy-based radioprotection.

Main Methods:

  • Review of existing research on radioprotectors, focusing on the shift from small molecules to gene therapy.
  • Analysis of the mechanisms by which gene therapy vectors can be engineered for targeted delivery.
  • Evaluation of the potential for gene augmentation or ablation to confer radiation resistance.

Main Results:

  • Gene therapy presents a flexible platform for developing targeted radioprotective agents.
  • The ability to precisely control gene expression offers enhanced control over protective responses.
  • Vector targeting and delivery improvements are key to realizing the full potential of gene therapy in radioprotection.

Conclusions:

  • Gene therapy is a highly promising strategy for enhancing radioprotection in cancer patients.
  • Further development in vector technology will be critical for clinical translation.
  • Targeted gene therapy offers a pathway to significantly reduce radiation-induced side effects.