Related Experiment Video
Updated: Apr 16, 2026
Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease
Published on: February 3, 2012
Orange-brown chromonychia and Kawasaki disease: a possible novel association?
Lucia Tessarotto1, Giulia Rubin2, Luca Bonadies2
1Department of Pediatrics, Ospedale Dell'Angelo, Mestre, Italy.
Insights
Kawasaki disease (KD) can cause orange-brown nail pigmentation, a finding not previously well-documented. This nail change may represent a late sign of KD, potentially aiding in future diagnoses.
Area of Science:
- Pediatrics
- Rheumatology
- Dermatology
Background:
- Kawasaki disease (KD) is an acute febrile vasculitis affecting medium-sized arteries, primarily in children.
- While characteristic clinical features of KD are well-established, less common or late-onset manifestations require further investigation.
- Nail changes, such as Beau's lines, have been reported in KD, but specific pigmentation patterns are not widely recognized.
Abstract:
A 4-year-old girl with clinical and laboratory signs of Kawasaki disease (KD) was hospitalized and given intravenous immunoglobulin plus aspirin therapy, with rapid defervescence and clinical improvement, and was discharged 48 hours after admission. At the time of her follow-up echocardiography on day 14, orange-brown pigmentation of the nail beds was noticed and confirmed with dermoscopy. No clear association between KD and orange-brown chromonychia has been demonstrated, although reports and case series suggest a possible link between these two entities. We suggest that this particular finding might be encompassed in late (subacute) changes of extremities as part of KD diagnostic criteria.
More Related Videos
08:43Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Published on: May 31, 2016
05:58Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format
Published on: August 20, 2018
Related Concept Videos
01:24Chronic Kidney Disease II: Clinical Manifestations
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
01:11Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
01:31Translation
Translation Produces the Building Blocks of Life
Proteins are...
01:31Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
01:17Karyotyping