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Interfacial Molecular-level Structures of Polymers and Biomacromolecules Revealed via Sum Frequency Generation Vibrational Spectroscopy

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Efficient screening of 2D molecular polymorphs at the solution-solid interface.

Shern-Long Lee¹, Jinne Adisoejoso, Yuan Fang

¹Department of Chemistry, Division of Molecular Imaging and Photonics, KU Leuven-University of Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium. Kunal.Mali@chem.kuleuven.be Steven.DeFeyter@chem.kuleuven.be.

|February 28, 2015

Summary

This summary is machine-generated.

This study introduces a simple method to screen for multiple two-dimensional (2D) crystalline polymorphs using solution flow. The technique enables rapid discovery and separation of diverse 2D crystal structures at the solution-solid interface.

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Area of Science:

Materials Science
Crystallography
Supramolecular Chemistry

Background:

Multiple polymorphs commonly form during two-dimensional (2D) crystallization of organic molecules.
Predicting polymorph occurrence and experimentally verifying them remain challenging.
Existing methods for 2D polymorph screening are limited.

Purpose of the Study:

To develop a straightforward experimental approach for screening 2D polymorphs.
To enable rapid discovery and nanoscale separation of multiple 2D polymorphs.
To demonstrate the method's versatility with different organic building blocks.

Main Methods:

Utilizing solution flow generated by contacting tissue paper to a sample.
Creating a lateral density gradient along the substrate surface in situ.
Employing this gradient for rapid screening and separation of 2D polymorphs.

Main Results:

Successfully screened 2D polymorphs for three structurally distinct organic building blocks.
Demonstrated rapid discovery and nanoscale separation of multiple 2D polymorphs in a single experiment.
Validated the effectiveness of the solution flow-induced density gradient method.

Conclusions:

The developed method offers a powerful tool for efficient screening of 2D polymorphs.
This approach simplifies the experimental verification of diverse crystalline structures.
Facilitates crystal engineering studies by enabling easier access to different 2D polymorphs.