Related Experiment Video

Updated: Apr 16, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Published on: March 27, 2020

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Transcription factors and chromatin proteins as therapeutic targets in cancer

Simon J Johnston1, Jason S Carroll1

  • 1Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.

Biochimica Et Biophysica Acta
|February 28, 2015
PubMed

Insights

Targeting gene transcription factors is a promising cancer therapy approach. Novel strategies are emerging to regulate transcription factor activity, with agents now in clinical use for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Gene transcription regulation is crucial in cancer development.
  • Transcription factors have historically been challenging therapeutic targets.
  • Recent advancements offer new strategies for targeting transcription factors in cancer.

Purpose of the Study:

  • To review emerging concepts in targeting gene transcription factors for cancer therapy.
  • To highlight clinical applications of agents targeting transcription factors.
  • To provide examples of successful clinical exploitation of these targets.

Main Methods:

  • Literature review of recent research on transcription factor regulation in cancer.
  • Analysis of emerging concepts and strategies.
  • Compilation of clinical examples of targeted agents.

Main Results:

  • Novel strategies for regulating transcription factor activity in cancer have been identified.
  • Several agents targeting transcription factors are currently in clinical use.
  • These targeted agents show promise in cancer treatment.

Conclusions:

  • Targeting gene transcription offers a viable therapeutic strategy in oncology.
  • Emerging approaches to modulate transcription factor activity are advancing cancer treatment.
  • Clinical exploitation of transcription factor-targeting agents is a growing area in cancer therapeutics.
Keywords:
CancerDrugsNuclear receptorsSmall moleculesTranscription factorssiRNA

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