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Published on: August 11, 2015
Intracranial aneurysms in the youngest patients: characteristics and treatment challenges
Bradley A Gross1, Edward R Smith, R Michael Scott
1Department of Neurological Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Mass., USA.
Insights
Pediatric aneurysms in children under 10 years old are distinct from adult types, often being fusiform/dissecting. Treatment approaches varied, with endovascular methods being common, and initial occlusion rates were high.
Area of Science:
- Pediatric Neurosurgery
- Cerebrovascular Diseases
- Medical Imaging
Background:
- Cerebral aneurysms in children present unique challenges compared to adults.
- Aneurysm characteristics and treatment strategies differ between younger and older pediatric populations.
Purpose of the Study:
- To characterize intracranial aneurysms in pediatric patients.
- To evaluate treatment strategies and outcomes for pediatric aneurysms.
Main Methods:
- Retrospective review of pediatric patients undergoing cerebral angiography from 2006-2014.
- Analysis of demographics, aneurysm presentation, subtype, treatment, and outcomes.
Main Results:
- 33 pediatric patients had intracranial aneurysms; 67% were fusiform/dissecting.
- Patients aged 0-10 years were more likely to have nonsaccular, dissecting/fusiform aneurysms (84% vs 43%).
- Endovascular treatment was used in 45% and microsurgery in 24%; 83% of aneurysms were occluded initially with 9% complications.
Conclusions:
- Youngest pediatric patients (≤10 years) harbor aneurysms more distinct from adult aneurysms than older pediatric patients.
- Findings highlight the unique nature of aneurysms in the youngest pediatric cohort.
Background:
Characteristics and treatment challenges of aneurysms in young children differ from those in older pediatric patients.
Methods:
Records of children undergoing cerebral or spinal angiography by the senior neurointerventionalist (D.B.O.) from October 2006 to January 2014 were reviewed to identify patients with digital subtraction angiography-confirmed intracranial aneurysms. Demographics, presentation, subtype of aneurysm, treatment strategy, and outcome were evaluated.
Results:
Of 763 pediatric cases, 33 were of children harboring cerebral aneurysms. Overall, 48% were male, 24% presented with hemorrhage and 67% harbored fusiform/dissecting aneurysms. Patients aged 0-10 years were significantly more likely to harbor nonsaccular, dissecting/fusiform aneurysms (84 vs. 43%, p = 0.02). A total of 13/22 pediatric patients harboring dissecting/fusiform aneurysms were male (59%) compared to 3/11 with saccular aneurysms (27%, p = 0.14). Overall, 15 patients underwent endovascular treatment (45%) and 8 underwent microsurgical treatment (24%). There was no significant difference in treatment approach based on patient age or aneurysm morphology. Overall, 19/23 aneurysms were occluded after initial treatment (83%); there were 2 procedure-related complications with neurological sequelae (9%).
Conclusion:
We demonstrate that the youngest patients (10 years and under) have aneurysms even more distinct and less similar to adult aneurysms than those in the larger pediatric cohort.
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