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Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
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The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
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Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
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KPC-producing Enterobacter aerogenes infection.

Felipe F Tuon1, Camila Scharf1, Jaime L Rocha2

  • 1Division of Infectious and Parasitic Diseases, Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brazil.

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
|February 28, 2015
PubMed
Summary
This summary is machine-generated.

Carbapenem-resistant Enterobacter aerogenes infections are a growing concern, particularly in older patients with comorbidities. High mortality rates underscore the need for prompt and effective treatment strategies for these difficult-to-manage nosocomial infections.

Keywords:
CarbapenemaseEnterobacterInfection controlKPC

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Area of Science:

  • Infectious Diseases
  • Microbiology
  • Clinical Medicine

Background:

  • Rising rates of carbapenem resistance in nosocomial pathogens like Enterobacter.
  • Limited clarity on optimal management strategies for carbapenem-resistant Enterobacter infections.

Purpose of the Study:

  • To evaluate clinical and epidemiological data of patients with KPC-producing Enterobacter aerogenes infections.
  • To identify risk factors associated with mortality in these patients.

Main Methods:

  • Retrospective and descriptive study design.
  • Molecular methods for KPC-2 detection.
  • Statistical comparison of risk factors for mortality.

Main Results:

  • 30-day mortality rate of 37.5% observed.
  • Age and Charlson comorbidity score were independent risk factors for death.
  • Five strains exhibited pan-resistance; all patients received monotherapy.

Conclusions:

  • Clinicians must be vigilant for carbapenem-resistant Enterobacteriaceae in elderly patients with comorbidities.
  • High mortality necessitates prompt and adequate therapeutic interventions.